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Treatment of Oral Lichen Planus With Paeoniflorin and Photodynamic Therapy

RecruitingNAAges 18 Years - anyAllPeking University Third Hospital
NCT05973097 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Oral lichen planus (OLP) is a common chronic inflammatory disease of the oral mucosa and is considered a precancerous condition. It is characterized by white reticular changes in the oral mucosa, which can progress to erosions and cause pain in severe cases. The pathogenesis of OLP is still unclear, but it is believed to be a T-lymphocyte-mediated autoimmune disease. Currently, only symptomatic treatments are available, and there is no definitive cure. In this project, we plan to use TCM differentiation to categorize OLP patients and conduct a randomized controlled clinical trial to demonstrate the enhanced therapeutic effect of paeoniflorin combined with photodynamic therapy for OLP. The implementation of this project will provide new insights into the clinical management of OLP, improve our understanding of the treatment mechanisms, and have important theoretical and clinical implicat

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📋 Eligibility rules (as published)
Inclusion Criteria: * patients with oral lichen planus * male or female patients older than 18 years of age * patients willing to participate with signed informed consent. Exclusion Criteria: * pregnant or lactating * had serious systemic diseases of the heart, lung, liver, and kidney, or had tumors * were unwilling to participate in the experiment.
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What it tests

  • total glucosides of paeony treatment
  • photodynamic therapy treatment
  • glucosides of paeony and photodynamic therapy combined treatment
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Where

1 site
Peking University Third Hospital
Beijing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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