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Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis

RecruitingNAAges any - anyAllChildren's Hospital of Philadelphia
NCT05975671 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this quasi-experimental interventional study is to determine the effectiveness of a multifaceted stewardship intervention in reducing overall vancomycin use in five tertiary care Pediatric Intensive Care Units (PICU). There are two groups of subjects in this study: PICU clinicians/sepsis stakeholders and patients admitted to one of the participating PICUs during the study period. The intervention will at a minimum include: * Implementation of a clinical guideline indicating when vancomycin should and should not be used * Unit-level feedback on overall vancomycin use within and across centers * Clinician education.

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📋 Eligibility rules (as published)
Patient Inclusion Criteria: * Admitted to one of the participating PICUs during the study period Patient Exclusion Criteria: * None Clinician Inclusion Criteria: 1. PICU prescribing clinician (including attending physicians, fellows, residents, nurse practitioners, and physician assistants) OR sepsis stakeholder (leader of sepsis quality improvement work, medical director) at one of the participating sites at the time the survey is deployed 2. Age ≥ 18 years old 3. Employed by one of the participating sites Clinician Exclusion Criteria: 1. Volunteers or other non-employee hospital staff 2. Limited English proficiency
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What it tests

  • Multifaceted de-implementation strategy to reduce vancomycin overuse
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Where

4 sites
Children's Healthcare of Atlanta
Atlanta, United States
Johns Hopkins Children's Center
Baltimore, United States
St. Louis Children's Hospital
St Louis, United States
Children's Hospital of Philadelphia
Philadelphia, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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