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A Study on the Bone-health Effectiveness of Applying Recombinant Factor VIII Fc (rFVIIIFc) to Patients With Hemophilia A (Prototype A)

Recruitingn/aAges any - anyMaleTri-Service General Hospital (TSGH)
NCT05981274 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Study Objectives\* 1. Provide a systematic evaluation of the treatment outcomes in patients with hemophilia A 2. Emphasize the importance and clinical benefits of rFVIII-Fc in joint and bone health. 3. Compare the clinical outcomes from 1 year before and after switching to EHL. 4. Exploratory: Identify biomarkers that could provide more useful and convenient evaluations of joint and bone health. (Time-saving and easy to monitor)

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Patients with severe hemophilia A (all ages). 2. Patients with moderate type hemophilia A with hemophilic arthropathy. 3. Currently on rFVIIIFc regular prophylaxis and have previous medical record with regular prophylaxis with standard half-life product for one year 4. Able and willing to undergo joint and bone examinations Exclusion Criteria: 1. Participants of other interventional studies. 2. Patients with current inhibitors. 3. History of major neurological disease (eg. Stroke, Parkinson's disease, neuropathy, etc.) 4. History of major psychiatric disease (eg. Schizophrenia, bipolar disorder) 5. Significantly impaired vision/hearing
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What it tests

  • serum biomarker.
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Where

1 site
Tri-Service General Hospital Hemophilia Care Center
Taipei, Taiwan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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