A Study on the Impact of Bivalirudin Usage During PCI for High-risk Plaques on Post-PCI Coronary Microcirculation.

Inclusion Criteria: 1. aged 18 years or older; 2. diagnosed with non-ST-segment elevation myocardial infarction or unstable angina pectoris; 3. scheduled to undergo elective coronary angiography and intervention; 4. coronary computed tomography angiography showing high-risk plaque features within 3 months prior to the procedure; 5. voluntary participation in the study and signed informed consent. Exclusion Criteria: 1. prior PCI of the target vessel within 3 months; 2. cardiogenic shock, active bleeding, bleeding disorders, irreversible coagulation dysfunction, severe liver dysfunction (Child-Pugh class C), severe renal dysfunction (eGFR \< 30 ml/min/1.73m2), and dependence on dialysis; 3. life expectancy less than 1 year; 4. chronic total occlusion of the target vessel; 5. poor opacification of the target vessel, severe vessel overlap or distortion, and inability to completely expose the lesion site; 6. allergy to contrast agents, verapamil, or its excipients; 7. severe uncontrolled hypertension (systolic blood pressure ≥ 160 mmHg and/or diastolic blood pressure ≥ 100 mmHg); 8. subacute bacterial endocarditis.