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Evolution of PET Fixation With FDG at the End of Antibiotic Treatment of Infective Endocarditis on Valvular Prosthesis

RecruitingNAAges 18 Years - anyAllAssistance Publique - Hôpitaux de Paris
NCT05989152 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In patients with prosthetic valve endocarditis (PVE) and pathological valvular FDG uptake on the initial FDG-PET and not referred to valve replacement at the acute phase, the study will assess whether FDG-PET is able to identify those at increased risk of PVE relapse.

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📋 Eligibility rules (as published)
"Inclusion criteria: * Patient aged 18 or over; * Have a prosthetic valve implanted surgically or by catheter for at least 3 months; * Presenting a definite IE on a prosthetic valve (ESC definition in force); * Having benefited from an FDG-PET examination for diagnostic purposes as part of the treatment revealing pathological hyperuptake at the level of the prosthetic valve AND carried out \<15 days after the start of antibiotic therapy for infective endocarditis; * Absence of cardiac surgical intervention performed for the current episode of AE or planned before the end-of-treatment FDG-PET Exclusion criteria: * Patient under legal protection, guardianship or curators; * Pregnancy, breastfeeding; * Patient not affiliated to a health insurance scheme or not a beneficiary of a social security scheme; * Simultaneous participation in a study on FDG-PET; * Absence of informed consent signed by the patient."
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What it tests

  • FDG-PET at the end of treatment for IE
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Where

1 site
Hôpital Bichat-Claude Bernard
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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