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Pituitary Function After Recovery From Septic Shock Among ICU Survivors

Recruitingn/aAges 18 Years - 80 YearsAllSanjay Gandhi Postgraduate Institute of Medical S…
NCT05990491 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Prolonged circulatory shock is associated with marked disturbances in vascular supply to the brain, and endothelial dysfunction which can lead to disseminated intravascular coagulation and microvascular thrombosis. Pituitary dysfunction is documented following post-partum hemorrhage, traumatic brain injury and subarachnoid hemorrhage, which also affect blood flow to the pituitary. However, there are no studies assessing pituitary function in the aftermath of recovery from shock. This will be a prospective observational study of patients admitted in Critical Care Medicine (CCM) ICU who have recovered from prolonged septic shock (Lasting for a period of \> 24 hours). Blood samples of the participants will be estimated at the time of discharge from the ICU and at 6 months post discharge. Investigators will estimate fasting serum cortisol, TSH, Free T4, Testosterone (in males), Oestrogen (in

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📋 Eligibility rules (as published)
Inclusion Criteria: Septic shock group: * Patients 18-80 years of age who meet the definition of septic shock. * Vasopressor requirement should be maintained for a period \> 24 hours and should require ICU stay for a duration of \> 7 days. * Patient should recover from shock and be planned for discharge from the ICU Non-septic shock group * Patients 18-80 years of age who planned for discharge from the ICU.with stay for a duration of \>7 days. * Also, they should not have received vasopressor for.a period of \>24 hours Exclusion Criteria: * Patients who refuse to provide consent. * Age \<18 years or \> 80 years of age. * Pregnancy or immediate post-partum (\< 6 months post-delivery). * Chronic kidney disease (Stage 5), chronic liver disease (CHILD B or C), severe Chronic obstructive pulmonary disease, Chronic heart failure. * Patients with pre-existing hypopituitarism on replacement. * Past history of severe post-partum hemorrhage requiring blood transfusion, traumatic brain injury, subarachnoid hemorrhage, pituitary tumor/surgery, snake bite envenomation and meningo-encephalitis. * Patients who have been on \> 5 mg prednisolone equivalent for a period of more than 2 weeks at any time in the previous 6 months before admission.
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What it tests

  • Not listed
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Where

2 sites
Department of Critical Care Medicine, SGPGIMS
Lucknow, India
Department of Endocrinology, SGPGIMS
Lucknow, India
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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