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The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium

RecruitingPhase 4Ages 65 Years - anyAllMedical University of Vienna
NCT05990790 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Patients over the age of 65 years are at increased risk for developing delirium after noncardiac surgeries, resulting in increased morbidity and mortality. The prevention of postoperative delirium has been classified as a public health priority. However, so far data regarding possible intraoperative interventions to reduce the incidence of postoperative delirium is very scarce. Due to the more rapid wash-in and wash-out times of desflurane as compared to sevoflurane or propofol it seems reasonable that desflurane might be beneficial for the prevention of postoperative delirium. Therefore, we evaluate the effect of maintenance of anesthesia using desflurane, sevoflurane or propofol on postoperative delirium in elderly patients undergoing moderate- to high-risk major noncardiac surgery.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Provide written informed consent * ≥65 years of age * Scheduled for elective major noncardiac surgery with estimated time of surgery ≥ 2 hours Exclusion Criteria: * Patients undergoing emergency surgery * BMI \> 45 kg/m\^2 * History of diagnosed dementia * Language, vision, or hearing impairments that may compromise cognitive assessments * History of malignant hyperthermia * History of structural muscle disease * History of organ transplantation (kidney, liver, lung, heart) * Patients undergoing hyperthermic intraperitoneal chemotherapy * ICU patients undergoing surgery
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What it tests

  • Desflurane
  • Sevoflurane
  • Propofol
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Where

2 sites
Medical University of Innsbruck
Innsbruck, Austria
Medical University of Vienna
Vienna, Austria
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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