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Objective Concussion Assessment Using MRI and Metabolomics

Recruitingn/aAges 9 Years - 50 YearsAllSt. Joseph's Healthcare Hamilton
NCT05993351 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Mild traumatic brain injury (mTBI), also referred to as concussions, affect millions of people around the world and can cause harmful long term effects. Unfortunately, concussions can be hard to diagnose and many people have lasting post-concussion symptoms such as headaches, difficulty concentrating, and light sensitivity. Recent studies have shown that advanced magnetic resonance imaging (MRI) techniques can identify subtle brain changes caused by a concussion. This study aims to track concussions over time measuring MRI brain scans and post-concussion symptoms to gain a better understand how the brain is affected in comparison to symptoms.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Aged between 9-50 * Recently sustained a concussion (within the last 2 weeks) Exclusion Criteria: * Aged 8 and younger or 51 and older * Unable to provide consent (e.g., poor English language skills, etc.) * History of liver or kidney disease * MRI contraindications: * Pacemaker * Stent * Joint prothesis * Implanted devices * Claustrophobia * Pregnant * Permanent piercings * Chronic/abusive use of alcohol and/or illicit drugs * Previous stroke or moderate/severe traumatic brain injury, subarachnoid hemorrhage, or intracranial hemorrhage * Healthy control participants must not have a concussion history or recently sustained a concussion
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What it tests

  • Magnetic resonance imaging (MRI)
  • Urine and saliva samples
  • Questionnaires
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Where

1 site
Imaging Research Center at St. Joseph's Healthcare Hamilton
Hamilton, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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