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Pharmacological Reversal of Neuromuscular Blockade in Critically Ill Patients

RecruitingNAAges 19 Years - 90 YearsAllSeoul National University Hospital
NCT05993390 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to compare the effect of use of reversal agents for neuromuscular blockade in critically ill patients on time for neurological assessment after endotracheal intubation The main questions it aims to answer are: * The use of reversal agents for neuromuscular blockade after endotracheal intubation may reduce the time for neurological assessment. * The types of reversal agents for neuromuscular blockade may affect the time for neurological assessment. Participants will receive different reversal agents or no medications based on the assigned groups. Thirty minutes after intubation using rocuronium, medication is administered, and the time of initial confirmation of eye opening and movement is recorded. Researchers will compare 3 groups (sugammadex, neostigmine and control(no medication) to see the difference of time for neurological assessment after end

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult patients 19 years of age or older who were intubated after admission to the intensive care unit. Exclusion Criteria: * Patients younger than 19 years of age * Patients who are not neurologically evaluable or have concomitant neurologic dysfunction * Patients with neuromuscular disorder * Patients with a history of drug allergic reactions to sugammadex or neostigmine * Patients taking or planning to take toremifene, fusidic acid, or hormonal contraceptives
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What it tests

  • Sugammadex
  • Neostigmine
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Where

1 site
Seoul National University Hospital
Seoul, South Korea
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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