AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

โ† Trials
๐Ÿงช

Study on Optimal Temperature During Cardiopulmonary Bypass (THERMIC-4)

RecruitingNAAges 18 Years - anyAllUniversity of Leicester
๐Ÿ’ฌ

In plain words

What the trial is, and whether it could suit you

In order to perform heart surgery, a machine called cardiopulmonary bypass (CPB), or more commonly known as a heart-lung machine, is used to maintain the circulation of oxygenated blood needed by the rest of the body and its organs. Historically, when a patient is connected to CPB, their body is cooled below the normal body temperature. This is known as hypothermia. This is because scientific studies have previously shown that reduced body temperature lowers metabolism and therefore offers more protection to the brain and other organs due to the reduced oxygen requirement. The evidence supporting this practice, however, has been challenged throughout the history of cardiac surgery, with studies supporting that normothermia, or normal body temperature, is a safe alternative. Despite this, the practice of hypothermia has persisted. Published data from a survey of 139 cardiac surgeons in t

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
INCLUSION CRITERIA Participants may enter the trial if all of the following apply 1. Adult patients (โ‰ฅ 18 years) scheduled for coronary artery bypass surgery and/or valve replacement/ repair, either in the elective or urgent setting. 2. European System for Cardiac Operative Risk Evaluation (EuroSCORE) II of 2 or higher. 3. Able to understand and communicate to provide informed consent. 4. Able to read and understand the English language. EXCLUSION CRITERIA Participants may not enter the trial if any of the following apply: 1. Patients undergoing coronary artery bypass surgery in combination with other procedures including cardiac or vascular procedures that require deep hypothermic arrest. 2. Patients undergoing emergency or salvage surgery. 3. Patients undergoing off-pump cardiac surgery. 4. Patients who are participating in another interventional trial. 5. Unable to provide informed consent.
๐Ÿ’Š

What it tests

  • Hypothermic Cardiopulmonary Bypass
  • Normothermic Cardiopulmonary Bypass
๐Ÿ“

Where

11 sites
Glenfield Hospital, University Hospitals of Leicester NHS Trust
Leicester, United Kingdom
Blackpool Victoria Hospital, Blackpool Teaching Hospitals NHS Foundation Trust
Blackpool, United Kingdom
University Hospitals Bristol and Weston NHS Foundation Trust
Bristol, United Kingdom
Castle Hill Hospital, Hull University Teaching Hospitals NHS Trust
Cottingham, United Kingdom
Golden Jubilee National Hospital, NHS Golden Jubilee
Glasgow, United Kingdom
King's College Hospital, King's College Hospital NHS Foundation Trust
London, United Kingdom
Royal Brompton Hospital, Guy's and St Thomas' NHS Foundation Trust
London, United Kingdom
Harefield Hospital, Guy's and St Thomas' NHS Foundation Trust
London, United Kingdom

โ€ฆand 3 more on ClinicalTrials.gov.

๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
๐Ÿ›ก๏ธ

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it โ€” not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use ยท Privacy