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CEST in Low-grade Glioma Study

RecruitingNAAges 12 Years - anyAllSunnybrook Health Sciences Centre
NCT05996653 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Low grade gliomas (LGGs) are malignant, infiltrative and incurable brain tumours that typically present in the younger population. This project proposes to use non-contrast metabolic "Saturation Transfer" (ST)-MRI to evaluate LGG tumour progression and aims to predict early changes in LGG. Early identification of LGG patients whose tumours will progress will permit early interventions. ST-MRI does not involve any intravenous injection of contrast and which acquires metabolic information not seen by standard MRI.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Be at least 12 years of age; 2. Diagnosed with: 1. Cohort A (pre-surgical): Suspected LGG (oligodendroglioma or astrocytoma), based on any combination of histological, molecular, radiological, and/or clinical findings; or 2. Cohort B (post-surgical): IDH1/2-mutant or IDH-wildtype (WT) low-grade glioma candidate for observation 3. No contraindications to MRI; 4. eGFR \> 30 ml/min; 5. No prior chemotherapy or radiation therapy; 6. No need for upfront treatment (surgery, chemotherapy, and/or radiation therapy) 7. Followed at either Sunnybrook Health Sciences Centre or at St Michael's Hospital Exclusion Criteria: 1. Need for upfront post-surgical treatment with either chemotherapy and/or radiation therapy 2. Pregnancy
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What it tests

  • Saturation Transfer (ST)-MRI
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Where

2 sites
Sunnybrook Health Sciences Centre
Toronto, Canada
St. Michael's Hospital
Toronto, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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