Exploring Cancer Evolution, Prognostic and Predictive Biomarkers in EGFR-mutant NSCLC

Inclusion Criteria: 1. Aged 18 years or older 2. Histologically or cytologically confirmed non-small-cell lung cancer 3. ECOG PS=0-2 4. EGFR mutations confirmed by tissue or peripheral blood 5. Can provide tumor tissue samples (fresh or archived) 6. The subject should have good compliance, who would participate in the research voluntarily, and sign the informed consent Exclusion Criteria: 1. History of other malignancies within 5 years (excluding basal cell carcinoma of the skin or other carcinoma in situ that has been resected). 2. Unable to provide sufficient tumor tissue for analysis. 3. Subjects with active, unstable systemic diseases, such as active infection, uncontrolled hypertension, heart failure (NYHA class \>= II), unstable angina pectoris, acute coronary syndrome, severe arrythmia, severe liver, kidney or metabolic diseases, HIV infection. 4. Subjects who are deemed unable to comply with the study requirements or complete the study.