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Attentional Mechanisms in SCD

RecruitingEARLY Phase 1Ages 55 Years - anyAllVanderbilt University Medical Center
NCT06002477 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study will use an anticholinergic pharmacological probe to examine attention network function in SCD using EEG. The overall hypothesis is that in older adults with SCD, normal cognitive performance is maintained by compensatory attention network activity, supported by enhanced cholinergic function. The investigators anticipate that SCD will be associated with greater compensatory attention network activity and that disrupting this compensatory process through anticholinergic challenge will result in a greater negative effect on attentional performance (Attention Network Test, ANT) and attention network functioning (EEG) in older adults with greater subjective cognitive concern.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. age ≥ 55 2. Montreal Cognitive Assessment (MoCA) \> 25 AND Global Deterioration Scale (GDS) rating \< 3 3. Non-smokers Exclusion Criteria: 1. medical contraindications to the drug challenge 2. primary neurological disorder (such as stroke, epilepsy, etc.)
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What it tests

  • Mecamylamine Challenge
  • Placebo Comparator Challenge
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Where

1 site
Vanderbilt University Medical Center
Nashville, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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