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Microfluidic Chip Method Versus Density-gradient Centrifugation Method in IVF

RecruitingNAAges any - 43 YearsAllProfessor Ernest Hung-Yu Ng
NCT06005311 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Infertile patients attending IVF treatment at the Centre of Assisted Reproduction and Embryology, Queen Mary Hospital and Kwong Wah Hospital will be recruited during ovarian stimulation for IVF. Subsequently, they will be randomly assigned on the day of oocyte retrieval by a laboratory staff into one of the following two groups: (1) the microfluidic chip group and (2) the density gradient group for sperm preparation and subsequent use in fertilization. Other IVF procedures will be the same as our usual practice. Both patients and clinicians were blinded from the group allocation i.e. a double blind study. The primary outcome is the cumulative live birth rate defined as the number of pregnancies leading to live birth within 6 months of randomisation.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Infertile women aged \<43 years at the time of ovarian stimulation for IVF Exclusion Criteria: * Women undergoing preimplantation genetic testing monogenic diseases, structural rearrangement of chromosomes or aneuploidy; * Male factor requiring surgical sperm retrieval such as microscopic epididymal sperm aspiration and testicular sperm extraction; * Use of donor oocytes and spermatozoa; * Submucosal fibroid or hydrosalpinx shown on pelvic scanning and not surgically treated; * Women who had been recruited into this study before and * Women joining other randomized trials
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What it tests

  • Microfluidic chip
  • Density-gradient centrifugation
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Where

1 site
Department of Obstetrics and Gynaecology
Hong Kong, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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