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The Effectiveness of the Letrozole-induced Endometrial Preparation Protocol in Frozen-thawed Embryo Transfer (FET)

RecruitingNAAges any - 40 YearsFemaleInternational Peace Maternity and Child Health Ho…
NCT06006091 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this single center, non-blinded, randomized controlled clinical trial to comparison of pregnancy outcomes and perinatal outcomes in patients undergoing IVF treatment (including ICSI) with FET with letrozole-induce endothelial preparation protocol versus natural cycles, hormone replacement protocol. The main questions it aims to answer are: * To investigate whether letrozole-induce endothelial preparation is effective in improving the live birth rate and clinical pregnancy rate. * To explore its possible impact on clinically important indicators such as spontaneous abortion rate, implantation cycle cancellation rate, days of endothelial preparation, and number of visits to the clinic. The study subjects were randomized into groups starting at D1-D3 of the menstrual cycle. The study subjects were stratified according to whether their menstrual cycles were regular or not, and

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📋 Eligibility rules (as published)
Inclusion Criteria: Women \<40 years of age undergoing IVF or ICSI at our reproductive center with a total of ≤3 superovulation cycles , and with ≥2 cleavage embryos or ≥1 blastocyst were cryopreserved. Previous cycles of embryo transfer ≤ 2 and only one transfer cycle with 1-2 embryos per study subject was enrolled. Exclusion Criteria: 1. Patients with chromosomal abnormalities in either spouse, hydrosalpinx, severe endometriosis, adenomyosis, and uterine and uterine cavity organic diseases such as uterine malformations, endometrial polyps, and uterine adhesions; 2. patients who underwent pre-implantation genetic diagnosis (PGT); 3. patients who underwent ICSI using surgically obtained epididymal or testicular spermatozoa; 4. patients with a Body mass index (BMI, = weight/height2 ) \> 30 kg/m2; 5. patients with recurrent spontaneous abortions; 6. patients with sequential embryo transfer.
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What it tests

  • Letrozole
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Where

1 site
Yu Xiao
Shanghai, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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