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Clinical Investigation of the Cardioprotective Effect of Early Administration of SGLT2 in Patients Presented With AMI

RecruitingNAAges 18 Years - 80 YearsAllMohammad Hussien Tantawy Soliman
NCT06009874 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

This study aims to investigate the effect of early administration of DAPA during ischemia and before pPCI on infarct size, reperfusion injury-related myocardial damage, cardioprotection from HF, and renoprotection from AKI in patients with AMI.

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Patients with ST-elevation myocardial infarction (STEMI). 2. STEMI was defined according to the Fourth Universal Definition of AMI. 3. 18 - 80 years of age. 4. Diabetics or non-diabetics. 5. eGFR \> 45 ml/min/1.73m2. 6. Blood pressure before first drug dosing \>110/70 mmHg. Exclusion Criteria: 1. Cardiogenic shock. 2. Hypoglycemia. 3. History of diabetic ketoacidosis. 4. Genital and urinary infections. 5. History of AMI. 6. Stent thrombosis. 7. Previous coronary artery bypass surgery. 8. Severe hepatic insufficiency. 9. Advanced cancer patients. 10. Blood pH \< 7.32. 11. Known allergy to SGLT-2 inhibitors. 12. Hemodynamic instability. 13. Females of childbearing potential without adequate contraceptive methods. 14. Patients currently on or have received any SGLT-2 inhibitors.
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What it tests

  • Dapagliflozin 10mg Tab
  • Placebo
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Where

1 site
Mohammad Soliman
Shibฤซn al Kawm, Egypt
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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