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Periodontitis and Inflammation: Study on Biological Samples

Recruitingn/aAges 18 Years - anyAllAssistance Publique - Hôpitaux de Paris
NCT06012019 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Periodontitis is a major public health problem because it is widespread in the adult population. It leads to the irreversible destruction of the anchoring tissues of the teeth, and represents a modifiable risk factor for systemic inflammatory pathologies. This chronic inflammatory disease, which is associated with oral dysbiosis involving Porphyromonas gingivalis, is triggered by a permissive immune response. It is preceded by a reversible clinical phase, during which there is no bone resorption process: gingivitis. The understanding of the key mechanisms involved in the evolution from gingivitis to periodontitis, which will allow to early identify patient at risk of periodontitis, remain unclear at this time. Neutrophils are the main cells of inflammation present within the periodontal pockets. The excess of certain neutrophils or the alteration of their functions is associated with th

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📋 Eligibility rules (as published)
Inclusion Criteria: Common criteria for all patient groups * Patient \> 18 years old * Patient affiliated to a national health insurance * Patient who speaks and understands French well enough to be able to read and understand the study information note. * Patient who does not object to his participation in the study Specific Criteria : * Control Group = BOP \< 10%, PI\<20%, PD≤ 3mm * Gingivitis cases = BOP ≥ 10%, PD≤ 3mm * Periodontitis cases = BOP ≥ 10%, PD\> 3mm Exclusion Criteria: * Patients who have received antibiotic prophylaxis, antibiotic therapy, or anti-inflammatory treatment within 3 months prior to inclusion * Pregnant or breastfeeding women * Patients suffering from a disease with defective neutrophil number, activity, activation or function * Patient deprived of liberty by judicial or administrative decision.
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What it tests

  • Biological sampling in Periodontitis Case
  • Biological sampling in Gingivitis Case
  • Biological sampling in Control Case
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Where

1 site
Charles-Foix Hospital
Ivry-sur-Seine, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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