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Volatile Sedation for Patients With the Acute Respiratory Distress Syndrome

RecruitingPhase 2, Phase 3Ages 17 Years - anyAllGuy's and St Thomas' NHS Foundation Trust
NCT06014138 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study will investigate how different types of routine sedation may affect patient's breathing whilst on a ventilator in the Intensive Care Unit (ICU). There are different approaches to sedation which may have advantages and disadvantages. During the study patients will receive both intravenous and inhaled volatile sedation (similar to anaesthetic 'gases' used for general anaesthesia) and the drive to breath, breathing efforts and function of the lung will be assessed.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult patients admitted to the Intensive Care Unit (ICU) * ARDS * Invasive mechanical ventilation (IMV) * Spontaneous breathing in pressures support mode (PSV) for less than or equal to 48 hours * Sedated with intravenous sedation (ie. propofol and / or midazolam and fentanyl or alternate short acting opioid) * Anticipated to remain on IMV and PSV and with a stable sedation score for a further 24 hours without planned sedation interruption / spontaneous breathing trial or other significant change in the level of ventilator support * Not receiving / anticipated to receive paralysis * In supine position Exclusion Criteria: * Personal or family history of malignant hyperpyrexia * Known or suspected elevated intracranial pressure * High dose vasopressors (ie. Noradrenaline \> 0.3mcg/kg/min or equivalent) * Contra-indication to oesophageal balloon (i.e. oesophageal / upper gastro-intestinal pathology) * Pregnancy * High dose oral sedatives (e.g. benzodiazepines) or opioids (e.g. oxycodone / oral morphine) which may affect respiratory drive
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What it tests

  • Propofol
  • Isoflurane
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Where

1 site
Guy's & St Thomas' NHS Foundation Trust
London, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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