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Purinergic Signaling and the Postmenopausal Heart

Recruitingn/aAges 30 Years - 88 YearsAllBeth Israel Deaconess Medical Center
NCT06015776 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

There is an increased risk of diastolic heart failure in post menopausal women. Estrogen plays a positive role in regulating molecular pathways in heart remodeling. Such pathways may work through purinergic signaling and its downstream effects on the heart's mitochondrial metabolism and angiogenic response to stress. Loss of estrogen functionality in post menopausal women may account for the increased risk of diastolic heart failure. The investigators will explore said pathways using cardiac tissue obtained from patients undergoing cardiac surgery.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients undergoing cardiac surgery under cardiopulmonary bypass. Exclusion Criteria: * Refusal to participate * Emergency surgery * Pre-existing heart block * Preexisting atrial fibrillation * Redo surgery * Estrogen or hormone replacement therapy * History of chronic heart failure * History of major kidney disease
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What it tests

  • Gender
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Where

1 site
Beth Israel Deaconess Medical Center
Boston, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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