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Investigation of Differential Biology of Benign and Malignant Renal Masses Using Advanced Magnetic Resonance Imaging Techniques

RecruitingNAAges 18 Years - anyAllUniversity of Cambridge
NCT06016075 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of this study is to develop techniques for non-invasive imaging of biology in participants with benign or malignant renal masses based on the novel scanning MRI techniques, including recently invented Hyperpolarised MRI, deuterium metabolic imaging and sodium MRI. This imaging study will: 1) acquire imaging data from human tissues following the injection of hyperpolarised 13C pyruvate and use 13C-MRI to monitor changes in the ratio of 13C-lactate to 13C-pyruvate; 2) acquire imaging data from human tissues using Sodium MRI or 3) acquire imaging data from human tissues following the oral consumable of deuterated glucose. Data acquired during this physiological study will be used to optimise future imaging protocols.In the UK and possibly in other countries, there are some patients with renal masses that are over treated or undergo unnecessary procedures such as surgery or biopsies,

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📋 Eligibility rules (as published)
Inclusion Criteria: * Over 18 years old * Able to and provide written informed consent to participate * If female, postmenopausal or if women of child bearing potential (WOCBP) using a suitable contraception * If male, using a suitable contraceptive method for the duration of the study * Radiologically suspected or pathologically confirmed benign or malignant renal masses, as determined by standard clinical practice * Capable of undergoing a minimum of one study visit Exclusion Criteria: * Contraindication or inability to tolerate MRI * Pregnant or actively breast-feeding woman * If using an intrauterine contraceptive device (IUCD) as a method of contraception the device should be MRI safe at 3 T (researcher to confirm) * Clinically significant cardiac, pulmonary or neurological diseases as determined by the investigators * Laboratory abnormalities that may impact on the study results * Any other significant medical or psychiatric history rendering the subject ineligible as deemed by the investigators
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What it tests

  • Hyperpolarised MRI
  • Sodium MRI
  • Deuterium metabolic imaging (DMI) MRI
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Where

1 site
University Department of Radiology
Cambridge, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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