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โ† Trials
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Coping After Loss Through Mindfulness in Adults With Prolonged Grief Disorder

RecruitingNAAges 18 Years - 60 YearsAllUniversity Hospital, Caen
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to pilot the effectiveness of an 8-week standardized Mindfulness Training program to decrease the psychiatric and somatic symptoms of prolonged grief disorder (PGD) and to examine changes in physiological and neuroimaging biomarkers of bereavement-related stress reactivity that are associated with Mindfulness Training in grieving adult patients (men and women, aged 18-60) who are diagnosed with PGD. The main questions it aims to answer are: 1. What is the effectiveness of Mindfulness Training to lower PGD symptom severity? 2. What is the effectiveness of Mindfulness Training on physiological and neuroimaging biomarkers of stress reactivity? 3. What are the potential mechanisms of treatment change of Mindfulness Training? Participants will be: * randomly assigned to immediately receiving an 8-week Mindfulness Training program or after a 12-week waitl

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Must have lost a loved one (spouse, romantic partner, parent, child, sibling, close friend) * Must have a score \>29 on the Inventory of Complicated Grief (ICG) * Clinical diagnosis of Prolonged Grief Disorder as assessed by the Structured Clinical Interview for Complicated Grief (SCI-CG) Exclusion Criteria: * History of a lifetime clinical diagnosis of schizophrenia * History of a lifetime clinical diagnosis of bipolar disorder * History of a lifetime clinical diagnosis of a psychotic disorder * Current diagnosis of substance or alcohol use disorder within the past 12 months * History of a neurologic disease, seizures, stroke or head injury resulting in prolonged loss of consciousness and/or neurological sequelae * Current pregnancy as assessed by a urinary pregnancy test at screening during the Screening (week -4 until 0), Baseline (week 0) or Endpoint visit (week 8), or lack of use approved methods birth control for women of childbearing age * Currently practice of mind-body techniques at least once a week (e.g., yoga) in the past 3 months * Currently undergoing concomitant psychotherapy for grief (any psychotherapy) * Left-handedness * Current use of medications that would affect cerebral metabolism * Any contraindications to Magnetic Resonance Imaging (MRI) * Being under legal guardianship
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What it tests

  • Meditation Training
  • Waitlist
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Where

1 site
CHU de Caen et Universitรฉ de Caen Normandie - Centre Esquirol Adult Psychiatry
Caen, France
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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