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The Role of Imaging in the Diagnosis, Management and Prognosis of Possible Non-convulsive Status Epilepticus

RecruitingNAAges 16 Years - anyAllUniversitaire Ziekenhuizen KU Leuven
NCT06017973 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The investigators propose a prospective study of 20 control subjects and 180 consecutive patients with possible non-convulsive status epilepticus (NCSE). The investigators will obtain three functional images of the brain: 1. Fluorodeoxyglucose positron emission tomography (FDG-PET) 2. Perfusion (and structural) magnetic resonance (MR) images 3. Computed tomography (CT) perfusion. Brain hypermetabolism/hyperperfusion is a strong argument to confirm a diagnosis of non-convulsive status epilepticus. The aim is to determine which of the three functional imaging techniques is the most sensitive and easy to obtain in the detection of hypermetabolism/hyperperfusion. The investigators will determine which EEG patterns are associated with hypermetabolism/perfusion. The investigators will further study and describe the management with antiseizure medication and outcome of the group with possib

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📋 Eligibility rules (as published)
Inclusion Criteria: \- The patient has possible non-convulsive status epilepticus with scalp or invasive EEG with ictal-interictal continuum patterns on EEG Exclusion Criteria: * The patient has a contra-indication for MRI such as metal implants * The patient has contrast sensitivity * The patiensuffers from claustrophobia or cannot tolerate confinement during PET-MRI scanning procedures
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What it tests

  • MRI scan including arterial spin labelling of the brain
  • CT perfusion scan of the brain
  • FDG-PET scan of the brain
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Where

1 site
University Hospitals Leuven, department of Neurology
Leuven, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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