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โ† Trials
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Molecular Culture for the Diagnosis of Pediatric Sepsis

Recruitingn/aAges 0 Years - 18 YearsAllJip Groen
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In plain words

What the trial is, and whether it could suit you

Babies and children have an increased risk of getting an infection with a bacteria in the bloodstream (sepsis). It is often difficult for the doctor to determine whether a child has an infection of the bloodstream, because the symptoms are often unclear and can also occur in children who are not sick. To determine whether there is an infection, a little blood is currently taken for a blood test (the blood culture) to investigate whether there is a bacteria in the blood. However, it often takes at least 36 hours before the results of this blood culture are available. That is why antibiotics are usually started immediately to treat the possible infection. However, it often turns out that the blood culture is negative after 36 hours, which means that no bacteria have been found in the blood. Usually the antibiotics are then stopped because it turns out that there was no infection at all. T

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Undergoing collection of blood for a conventional blood culture as part of standard care OR * Having undergone sepsis evaluation collection of blood for a conventional blood culture as part of standard care in the past 72 hours Exclusion Criteria: * Apart from an age criterion, there are no strict exclusion criteria. However, for the analysis of the secondary outcome (I.e. the testing of diagnostic accuracy of both MC as well as conventional culture for clinical sepsis), we plan to exclude all children who ultimately have a clear alternative cause for clinical illness that does not directly result from bacteraemia or bacterial sepsis. This will remain true in the case of conventional culture positivity, either when considered a contaminant as well as when considered a contributing factor in the presence of any of the causes of clinical illness mentioned below. A potential subject who meets any of the following criteria will be excluded from participation in this study These causes include, but are not limited to: * In case of the potential inclusion of a neonate suspicious for EOS, confirmed congenital infection with TORCHES (toxoplasmosis, rubella, cytomegalovirus, syphilis and herpes) will lead to exclusion particularly for the neonatal population * Auto inflammatory disease * Hemophagocytic syndrome * SIRS (Systemic Inflammatory Response Syndrome following a severe viral infection
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What it tests

  • Molecular Culture
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Where

2 sites
Amsterdam UMC
Amsterdam, Netherlands
Spaarne Gasthuis
Haarlem, Netherlands
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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