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Standard Dose Continuous Renal Replacement Therapy (CRRT) Versus Low-Dose CRRT ( KETZEREI )

RecruitingNAAges 18 Years - anyAllUniversität Münster
NCT06021288 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Acute kidney injury (AKI) is a well-recognized complication in critically ill patients, which often leads to the necessity of mechanical kidney support (CRRT). In current therapeutic regimes, CRRT is used to strictly prevent azotaemia. Thus recent clinical observations, as well as data from animal testing suggest a link between controlled azotaemia and faster renal recovery in AKI patients. The aim of the study is to improve renal recovery.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult patients (age ≥18 years) * Critically ill patients with AKI + in need of CRRT * Written informed consent Exclusion Criteria: * Chronic dialysis dependency * Chronic kidney disease with estimated glomerular filtration rate (eGFR) \<30 ml/min/1.73m² * severe liver cirrhosis (Child-pugh C) * severe acidosis (pH \< 7,20 at study enrolment) * severe hyperkalaemia (\> 6mmol/l) * Pregnancy or breastfeeding * persons held in an institution by legal or official order * Dependency on the investigator or center
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What it tests

  • Effluent dose of CRRT
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Where

2 sites
University Hospital Münster
Münster, Germany
Universitätsklinikum Tübingen; Universitätsklinik für Anästhesiologie und Intensivmedizin
Tübingen, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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