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Microfluidic Chip vs Density Gradient Centrifugation on the Euploidy Rate of Pre-implantation Genetic Testing

RecruitingNAAges any - 43 YearsAllProfessor Ernest Hung-Yu Ng
NCT06023472 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Infertile women attending for PGT at the Centre of Assisted Reproduction and Embryology, Queen Mary Hospital and Kwong Wah Hospital will be recruited during ovarian stimulation for IVF. Subsequently, they will be randomly assigned on the day of oocyte retrieval by a laboratory staff into one of the following two groups in a 1:1 ratio : (1) the microfluidic chip group and (2) the density gradient centrifugation group for sperm preparation and subsequent use in fertilization. Other IVF procedures will be the same as the standard practice of the Centre. Both women and clinicians will be blinded from the group allocation i.e. a double blind study.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Women aged \<43 years at the time of ovarian stimulation for IVF * Women undergoing PGT for monogenic diseases, structural rearrangement of chromosomes or aneuploidy * Sperm concentration of the raw semen with at least 0.15 million motile sperm per ml or 100 motile sperm per 50 low power field (200x) of observation Exclusion Criteria: * Use of frozen semen for insemination * Use of donor oocytes and spermatozoa * Submucosal fibroid or hydrosalpinx shown on pelvic scanning and not surgically treated; * Women who had been recruited into this study before and * Women joining other randomized trials
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What it tests

  • microfluidic chip
  • density gradient centrifugation
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Where

1 site
Department of Obstetrics and Gynaecology
Hong Kong, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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