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Analysing Peripheral Skeletal Muscle Function Before and After Endobronchial Valve Treatment

Recruitingn/aAges any - anyAllUniversity Medical Center Groningen
NCT06025500 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Rationale: Chronic obstructive pulmonary disease (COPD) is characterised by a high prevalence of peripheral muscle dysfunction, which can have significant clinical consequences, including decreased exercise capacity, reduced quality of life, and even a higher mortality rate. Reduction of lung hyperinflation using bronchoscopic lung volume reduction treatment with one-way endobronchial valves (EBV) is a minimally invasive intervention which improves exercise capacity and physical activity in patients with severe emphysema. This positive effect is also related to weight gain and alterations in body composition. The physiologic and structural adaptations of skeletal muscle function after EBV treatment has never been investigated before. Objective: To investigate the physiological and structural adaptations of peripheral muscle function at a cellular level in response to EBV treatment. Stu

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patient is scheduled for a bronchoscopic lung volume treatment using one-way endobronchial valves; * Patient read, understood and signed the Informed Consent Form. Exclusion Criteria: * Inability to perform a cycle ergometry test; * Contraindications for undergoing a magnetic resonance imaging scan (e.g. claustrophobia, implanted cardiac devices); * Body length \>190cm; * Any anticoagulant therapy; * COPD exacerbation 4 weeks prior to testing.
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What it tests

  • 31P-Magnetic Resonance Spectroscopy (31P-MRS)
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Where

1 site
Univeristy Medical Center Groningen
Groningen, Netherlands
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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