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Blood Flow Regulation and Neuromuscular Function Post-Stroke

RecruitingNAAges 18 Years - 85 YearsAllMedical College of Wisconsin
NCT06027294 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The muscles of stroke survivors can fatigue faster compared to muscles in people who have not had a stroke, which can limit how long a person with stroke can perform tasks such as walking. This study will examine how blood flow is regulated to the exercising leg muscle post-stroke, because if the muscle does not receive enough blood flow it will become fatigued. Finally, the investigators will use a safe and simple non-invasive intervention called ischemic conditioning, which has known effects to improve blood flow to exercising muscle and determine the effects on muscle fatigue.

Sign in to get the eligibility rules as simple questions to take to your doctor.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Be between 18-85 years of age * Able to give informed consent * ≥6 months post diagnosis of unilateral cortical or sub-cortical stroke * English speaking Exclusion Criteria: * History of blood clots in the extremities or any condition in which compression of the thigh or transient ischemia is contraindicated (e.g. wounds in the leg) * Chronic pain syndrome * Low back or hip pain that interferes with lower extremity motor testing * History of head trauma * Comorbid neurological disorder * Peripheral vascular disease * Myocardial infarction in the previous year * Inability to follow 2 step commands * Condition where fatiguing contractions or resisted leg contractions are contraindicated * Resting SBP ≥160 mmHg or DBP ≥ 110 mmHg * Pregnancy or breastfeeding.
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What it tests

  • Ischemic Conditioning
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Where

2 sites
Medical College of Wisconsin
Milwaukee, United States
Marquette University
Milwaukee, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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