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Clostridioides Difficile Infection: Analyzing CLInic Evolution and Bacterial Clearance

Recruitingn/aAges 18 Years - anyAllFondation Hôpital Saint-Joseph
NCT06030245 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Clostridioides difficile (formerly Clostridium) is a bacterium found in the form of spores (resistance form) in the environment to which patients may be exposed. This bacterium used to belong to the Clostridium genus, but analysis of its 16S ribosomal RNA in 2016 led to its being distinguished from it. Once the spore has been ingested, it can germinate in vegetative form (the active form of the bacterium), taking on the appearance of a Gram-positive bacillus that will colonize the digestive microbiota. This preliminary stage of digestive colonization by the bacteria is facilitated by certain factors, notably nasogastric probing, antacids, etc. Antibiotics, for their part, disrupt the bacteria of the digestive microbiota (dysbiosis), thus facilitating the implantation of C. difficile. Certain strains (known as toxigenic) will produce the main virulence factors: toxins A (TcdA) and B (TcdB

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients over 18 years of age * Patients hospitalized in a department of GH Paris Saint-Joseph with a microbiologically documented Clostridioides difficile infection or a microbiologically documented Clostridioides difficile recurrence. * Patient to be treated for Clostridioides difficile infection * French-speaking patient * Patients who do not object to their participation in the study Exclusion Criteria: * Patients under guardianship or curatorship * Patient deprived of liberty * Patient under court protection * Pregnant or breast-feeding patient
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What it tests

  • Not listed
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Where

1 site
Fondation Hôpital Saint-Joseph
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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