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Remote Ischemic Conditioning in Aneurysmal SAH

RecruitingNAAges 18 Years - anyAllAarhus University Hospital
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to examine the effect of limb occlusion therapy (remote ischemic conditioning, RIC) in subjects with aneurysmal subarachnoid hemorrhage. The main question it aims to answer is whether RIC can improve long-term recovery in participants with aneurysmal subarachnoid hemorrhage. Researchers will compare levels of functional independence in participants in the RIC-group to participants in the sham-group.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Aneurysmal subarachnoid hemorrhage confirmed by computed tomography (CT) with aneurysm origin confirmed by computed tomography angiography (CTA) or digital subtraction angiography (DSA) * Aneurysmal subarachnoid hemorrhage symptom-onset โ‰ค 3 days * Aneurysm protected by clipping or coiling * Independent in daily living before symptom onset (mRS โ‰ค 2) Exclusion Criteria: * Subarachnoid hemorrhage caused by a lesion other than cerebral aneurysm * Symptomatic vasospasm at the time of enrollment * Previous cerebral lesion e.g. symptomatic cerebral infarction (\>2cm), multiple sclerosis, symptomatic intracerebral hemorrhage, tumour, prior neurosurgery (excluding prior clipping or coiling of cold aneurysms without complications). * History of severe peripheral vascular disease or signs of severe peripheral vascular disease on physical examination * History of deep vein thrombosis or signs of deep vein thrombosis on physical examination * Kidney involvement or prior kidney disease with an estimated glomerular filtration rate (eGFR) below safe levels for contrast infusion in relation to CT-perfusion. * Pregnancy (Women of child-bearing age will have serum-Humane Choriogonadotropine taken prior to final inclusion. If pregnancy cannot be ruled out,the patient can't be included. Women with a safe birth control method will be encouraged to use this method during the entire period of active treatment.) * Concomitant other acute life-threatening medical or surgical condition
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What it tests

  • Remote Ischemic Conditioning with Automatic Tourniquet Device
  • Sham Remote Ischemic Conditioning with Automatic Tourniquet Device
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Where

1 site
Department of Neurosurgery, Aarhus University Hospital
Aarhus N, Denmark
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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