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โ† Trials
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Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis

Recruitingn/aAges 50 Years - anyAllColumbia University
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In plain words

What the trial is, and whether it could suit you

Primary objective: To identify older adults with transthyretin cardiac amyloidosis (ATTR-CA) early in the course of the illness, at a time when disease modifying therapies are most effective. The specific aims of this epidemiologic investigation include: 1. To identify subjects with previous lumbar spinal stenosis (LSS) Surgery who have evidence of transthyretin (TTR) amyloid deposits in spinal specimens and could be at risk for ATTR cardiac amyloidosis. 2. To evaluate for ATTR-CA among those with localized TTR in the spinal tissue. The study will also explore the following: 1. The prevalence of amyloid in lumbar spinal stenosis specimens by Congo Red staining. 2. The prevalence of TTR deposits among subjects with amyloid as determined by mass spectrometry. 3. Evaluation of a novel artificial intelligence technique for that can identify amyloid histologically with standard H\&E stai

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Clinically indicated spinal decompressive surgery within 20 years prior to enrollment. 2. Age โ‰ฅ50 years at the time of the surgery. 3. Able to understand and sign the informed consent document after the nature of the study has been fully explained. Exclusion Criteria: The presence of any of the following excludes eligibility for enrollment in this study: 1. Confirmed primary amyloidosis (AL) or secondary amyloidosis (AA). 2. Known TTR amyloidosis. 3. Other reason that would make the subject inappropriate for entry into this study.
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What it tests

  • Tc99-PYP or Tc99-HDMP Scan
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Where

6 sites
Cedars-Sinai Medical Center
Beverly Hills, United States
Tufts Medical Center
Boston, United States
Boston Medical Center
Boston, United States
Mayo Clinic
Rochester, United States
Columbia University Irving Medical Center
New York, United States
Cleveland Clinic
Cleveland, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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