Oxytocin Substitution Therapy in Patients With Central Diabetes Insipidus

Inclusion Criteria: * Adult patients with a confirmed diagnosis of central diabetes insipidus based on accepted criteria * Heightened anxiety levels (STAI - Trait subscale ≥ 39 score points) or alexithymia levels (impaired ability to identify and describe feelings; TAS-20 total ≥ 52 score points) * Stable hormone replacement therapy for at least three months with desmopressin and, in case of additional anterior pituitary deficiencies, with the respective substitution therapies. Exclusion Criteria: * Participation in a trial with investigational drugs within 30 days * Active substance use disorder within the last six months * Consumption of alcoholic beverages \>15 drinks/week * Current or previous psychotic disorder (e.g., schizophrenia spectrum disorder) * Pregnancy and breastfeeding within the last eight weeks * Unwilling to use a medically acceptable form of contraception throughout the study period (female of childbearing potential only) * Prolonged QTc-time \>470 ms assessed with a 12-lead electrocardiogram.