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Total Intravenous Versus Inhalational Anesthesia- A Geriatric Anesthesia Study

RecruitingPhase 4Ages 70 Years - 110 YearsAllOregon Health and Science University
NCT06036095 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Traditionally, general anesthesia is maintained with inhalational anesthesia (GAS), but there is a gap in knowledge regarding whether intravenous anesthesia (IV) can prevent deleterious postoperative outcomes in the geriatric surgical population. The goal of this clinical trial is to determine whether intravenous anesthesia (IV) leads to a decreased incidence of postoperative delirium (POD), postoperative cognitive dysfunction (POCD), and functional decline, and improved patient-reported outcomes (PROs) in older adults undergoing non-cardiac surgery when compared to the standard inhalational anesthesia (GAS). This single-center, 1:1 randomized, double-blind (patient \& outcome assessor) clinical trial will compare inhalational vs. intravenous anesthesia on POD, POCD, functional status, patient-reported outcomes (PROs), and blood-based biomarkers in older patients undergoing elective, inp

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📋 Eligibility rules (as published)
Inclusion criteria: * Men and women ≥ 70 years * Sufficient vision and hearing to complete all tests * Proficient in spoken and written English * Scheduled for elective, inpatient, noncardiac surgery, expected to last at least 120 minutes requiring general anesthesia Exclusion criteria: * Urgent or emergent surgery * Diagnosed dementia (or MoCA\<19) * History of Parkinson's disease, major psychiatric disease (Schizophrenia), or severe traumatic brain injury * Ongoing alcohol or substance abuse (per DSM V criteria) * Allergy to propofol or sevoflurane * Personal or family history of malignant hyperthermia * Planned postoperative intubation * Brain surgery * Surgery requiring TIVA or GAS (i.e. cases involving neuromonitoring) * Surgical procedure requiring general anesthetic occurring within 3 months (before or after) surgical date * Any patient or perioperative factor considered a contraindication to randomization to either experimental group by the surgeon or anesthesiologist.
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What it tests

  • Sevoflurane
  • Propofol
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Where

1 site
Oregon Health & Science University
Portland, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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