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Evaluation of Integrated Versus Parallel Connection for Renal Replacement Therapy in ECMO Patients

RecruitingNAAges 18 Years - anyAllHospices Civils de Lyon
NCT06038162 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Extracorporeal membrane oxygenation (ECMO) is an extra-corporeal assistance used in case of respiratory or circulatory failure. In case of circulatory failure, ECMO is in the veno-arterial configuration (VA-ECMO). VA-ECMO patients are at high risk of developing acute kidney injury (AKI) and renal replacement therapy (RRT) may be needed in 50% of ECMO patients. Although the administration of RRT in ECMO patients has major implications, no specific recommendations are currently available. The 2020 Kidney Disease: Improving Global Outcomes (KDIGO) international conference identified the evaluation of RRT in these ECMO patients as a research priority. In 2023, the two main configurations used to administer RRT in ECMO patients are an independent delivery on a separate vascular access (parallel connection) or an integration of the RRT machine directly into the ECMO circuit (integrated connec

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients aged above 18 years * Patient on VA-ECMO who requires the initiation of continuous RRT during VA-ECMO treatment * Patient with a foreseeable length of stay in intensive care greater than 24 hours Exclusion Criteria: * Patient who does not have a vascular capital allowing for the insertion of a new dialysis catheter to administer RRT and therefore cannot be randomized to the parallel connection group * High pressures monitored on ECMO not allowing direct RRT catherter on ECMO * Pregnant, parturient, or breastfeeding women * Patient deprived of liberty by a judicial or administrative decision * Patient under psychiatric care * Patient subject to a legal protection measure (guardianship, curators) * Patient not affiliated to a social security system * Patient participating in another interventional research study in the field of extra purification renal
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What it tests

  • Parallel connection
  • Integrated connection
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Where

12 sites
CHU de Bordeaux, GH Sud, Service d'anesthésie-réanimation cardiovasculaire, Hôpital cardiologique
Bordeaux, France
CHU de Clermont Ferrand, Pôle de médecine péri-opératoire/Chirurgie cardiaque, Hôpital Gabriel Montpied
Clermont-Ferrand, France
Centre Hospitalo Universitaire de Dijon, Unité Réanimation Cardio-Vasculaire,
Dijon, France
CHU de Grenoble, Service de réanimation cardiovasculaire et thoracique, Pôle anesthésie réanimation, Hôpital Nord
Grenoble, France
Centre Hospitalo Universitaire de Lille, Institut Coeur Poumon
Lille, France
Hospices Civils de Lyon, Service d'Anesthésie-Réanimation cardiovasculaire, Hôpital Louis Pradel
Lyon, France
CHU de Montpellier, Département d'anesthésie-réanimation, Pôle Cœur-poumons, Hôpital Arnaud de Villeneuve
Montpellier, France
APHP, Institut de Cardiologie, Service d'anesthésie-réanimation cardiovasculaire, Hôpital de la Pitié-Salpêtrière
Paris, France

…and 4 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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