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Optimizing Pain Self-Management in Total Knee Arthroplasty

RecruitingNAAges 18 Years - 85 YearsAllUniversity of Virginia
NCT06038240 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to investigate the efficacy of a positive affect enhancing intervention designed to reduce pain and augment reward system function in knee osteoarthritis (KOA) patients undergoing total knee arthroplasty (TKA). The scientific premise is that patient use of a positive emotion generative practice - savoring meditation, which has been demonstrated to reduce pain in experimental laboratory settings, enhanced with a pain neuroscience education component about reward system dysfunction as a chronic pain mechanism - is optimally suited to reduce postsurgical pain and augment reward system functioning relative to a Pain Self-Management and Education (PSME) condition. We will randomize 150 patients with KOA undergoing unilateral TKA to a brief, 4-session (20-30 minutes each) course of Savoring Meditation (SM; n = 75) or PSME (n = 75) delivered remotely by trained inte

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📋 Eligibility rules (as published)
Inclusion Criteria: * 18-85 years old. * Have a physician-confirmed treatment plan to undergo unilateral TKA along with physician-confirmed knee osteoarthritis diagnosis. * Willingness and ability to comply with scheduled sessions and study procedures Exclusion Criteria: * Member of a vulnerable population including pregnant women, children, prisoners, cognitively impaired, and non-English-speaking subjects. * Current unstable, severe medical comorbidity. * Current severe psychiatric comorbidity (e.g., schizophrenia, psychosis, or other unstable psychiatric disorder). * Current severe alcohol or substance use disorder. * Weekly or more frequent use of opioids in the past 30 days (other than tramadol and/or codeine) for therapeutic or non-therapeutic purposes. * Other surgery of the affected knee in the last 6 months. * Previous TKA.
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What it tests

  • Savoring Meditation
  • Pain Self-Management and Education
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Where

1 site
Fontaine Research Park
Charlottesville, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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