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Pathogenic Metagenomic Next-generation Sequencing to Optimize the Diagnosis of Decompensated Cirrhosis Infection

Recruitingn/aAges 18 Years - 80 YearsAllNanfang Hospital, Southern Medical University
NCT06039696 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this observational study is to learn about clinical application of pathogenic metagenomic next-generation sequencing to optimize the diagnosis of infection in decompensated cirrhotic patients. The main questions it aims to answer are: 1. mNGS testing in optimizing anti-infective drug use in patients with acute decompensation, including response to empiric antibiotic therapy. 2. Proportion of patients with re-compensation. 3. The positive rate of mNGS in patients with acute decompensated cirrhosis and the characteristics of pathogen. 4. The incidence, risk factors and clinical correlation of CMV reactivation.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years old. * Diagnosis of cirrhosis, previously known or not, of any etiology, histologically proven or not. * Acute decompensation: ascites, digestive hemorrhage or hepatic encephalopathy. Exclusion Criteria: * Age \> 80 years old. * Malignancy of liver or other organs (including leukemia). * Receiving immunosuppressive agents for non-hepatic diseases. * HIV infection.
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What it tests

  • Not listed
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Where

1 site
Nanfang Hospital
Guangzhou, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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