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โ† Trials
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Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

RecruitingPhase 1Ages 18 Years - anyAllRevolution Medicines, Inc.
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In plain words

What the trial is, and whether it could suit you

This study is to evaluate the safety and tolerability of RMC-9805 as monotherapy and in combination with RMC-6236 in adults with KRAS G12D-mutant solid tumors.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Pathologically documented, locally advanced or metastatic solid tumor with a KRAS G12D-mutation * Received and progressed or been intolerant to prior standard therapy (including targeted therapy) appropriate for tumor type and stage * ECOG performance status 0 or 1 * Adequate organ function Exclusion Criteria: * Primary central nervous system (CNS) tumors * Known or suspected leptomeningeal or active brain metastases or spinal cord compression * Known or suspected impairment of gastrointestinal function that may prohibit ability to swallow or absorb an oral medication * Participant was previously treated with an investigational KRAS G12D inhibitor, pan- or multi-RAS inhibitor, or had prior therapy with any direct RAS-targeted therapy (eg, degraders and inhibitors) Other inclusion/exclusion criteria may apply.
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What it tests

  • RMC-9805
  • RMC-6236
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Where

17 sites
University of California, Davis Comprehensive Cancer Center
Sacramento, United States
Smilow Cancer Hospital (Yale University)
New Haven, United States
Florida Cancer Specialists
Sarasota, United States
Lee Moffitt Cancer Center
Tampa, United States
Johns Hopkins University
Baltimore, United States
Massachusetts General Hospital
Boston, United States
Dana-Farber Cancer Institute
Boston, United States
NYU Langone
New York, United States

โ€ฆand 9 more on ClinicalTrials.gov.

๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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