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MRI Guided Radiotherapy and Radiobiological Data: the ISRAR Database (Irm Sequences for Radiobiological Adaptative Radiotherapy)

Recruitingn/aAges 18 Years - anyAllHospices Civils de Lyon
NCT06041555 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The MRI linac Unity is a major technological evolution in radiotherapy combining a linear accelerator with a 1.5T MRI (radiological quality). It allows to target the target volume more precisely and to adapt the daily dose distribution according to variations in the position and volume of the tumor, critical organs and the tumor response. In many studies conducted in radiology, the analysis of specific MRI sequences, particularly in radiomics, aims to characterize tumors and their sensitivity to treatment. Initial data show that in radiotherapy, it would eventually be possible to characterize the radiosensitivity of healthy and tumorous tissues. With linac 1.5T MRI, the performance of selected MRI sequences, at each session, could make it possible to identify different levels of radiosensitivity within the tumour. The reproduction of these sequences on a daily basis could make it possibl

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📋 Eligibility rules (as published)
Inclusion Criteria: * 18years old or older * diagnosed with prostate, kidney, cervix, head and neck cancer or glioblastoma * indication of external radiotherapy * treated with the Linac UNITY MRI guided radiotherapy at the centre hospitalier Lyon Sud des Hospices Civils de Lyon * agreement of the patient to participate * affiliated to a social security system Exclusion Criteria: patient unable to keep a lying position during all the procedure * patient under law restriction * pregnant women or breastfeeding
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What it tests

  • 3 MRI sequences (T2*, IVIM and Multi Echo-Gradient), without injection, are performed
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Where

1 site
Hôpital Lyon Sud/ service de Radiothérapie Oncologie
Lyon, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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