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Novel, One Stop, Affordable, Point of Care and AI Supported System of Screening, Triage and Treatment Selection for Cervical Cancer in LMICs

RecruitingNAAges 25 Years - 49 YearsFemaleInternational Agency for Research on Cancer
NCT06042543 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Artificial intelligence (AI) is fast gaining reputation as a highly promising solution for cervical cancer screening. AI-based detection of cervical neoplasias is named automated visual exam (AVE) by the National Cancer Institute, USA. The investigators propose to develop and evaluate the performance characteristics of a novel AI system to both screen and triage women as well as help in treatment decision making. AI will analyse infrared spectroscopic signals derived from urine samples of unscreened women for the presence of high-risk human papillomavirus (hr-HPV). Our preliminary study has shown that spectroscopy can detect hr-HPV in urine. For screen-positive women the AI will interpret a set of cervical images captured with a high-quality devoted camera to detect high grade cervical precancers and cancers and to determine the type of transformation zone (TZ) (helps in treatment decisi

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📋 Eligibility rules (as published)
Inclusion Criteria: * No cervical screening during the previous 3 years * Between the ages of 25 and 49 years * Understands and signs a written informed consent form Exclusion Criteria: * Refusal to take part for any reason * Actively menstruating or pregnant * Treated earlier for cervical precancer or cancer
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What it tests

  • Screening with HPV test
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Where

2 sites
University of Cincinnati
Cincinnati, United States
University of Zimbabwe
Harare, Zimbabwe
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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