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Multi-parametric MRI Evaluation of Renal Graft Performance After Living Donor Donation.

RecruitingNAAges 18 Years - anyAllHospices Civils de Lyon
NCT06047106 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The selection of kidneys from living donors is based on strict glomerular filtration rate (GFR) values, in the setting of the increasing proportion of older donors. The 2017 KDIGO recommendations consider that approving kidney donation for a donor with a GFR between 60 and 89 mL/min/1.73 m² should be individually discussed, possibly using a calculator. A GFR \< 60 mL/min/1.73 m² should contraindicate donation without considering the donor's age. GFR physiologically decreases with age, so older donors frequently have a GFR below 90 ml/min/1.73 m². However, the proportion of older donors continues to rise. Kidney grafts from older living donors maintain better renal function than those from deceased donors, aiming to counteract the organ shortage. Kidneys possess functional reserves, allowing an increase in GFR during stimulations and adaptation to reduced functional nephron count (as a

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📋 Eligibility rules (as published)
Inclusion Criteria: For recipients: * Patients with end-stage chronic kidney disease awaiting kidney transplant from a living donor. * Adult patient * Consent signed * effective contraceptive method for women * Patient affiliated to a social security or beneficiaries of a similar scheme For donors: * Individuals eligible for living kidney donation with GFR \> 60 mL/min/1.73 m². * Adult patient * Consent signed * effective contraceptive method for women * Patient affiliated to a social security or beneficiaries of a similar scheme Exclusion Criteria: For the two groups : * MRI contraindications (claustrophobia, pacemaker, cardioverter defibrillators implantable, mechanical heart valve non MRI-compatible) * Weight\> 130 kg * Pregnant, parturient or breastfeeding * Persons deprived of their liberty by a judicial or administrative decision, * Adults subject to a legal protection measure (safeguard measure, guardianship, curators) * subject participating in another research including an exclusion period still in progress at inclusion For recipients : \- Contraindication to renal graft biopsy (ongoing or uninterrupted anticoagulant or antiplatelet treatment, thrombocytopenia \<100 x 10\^9/L, anemia \<7 g/dL).
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What it tests

  • multiparametric MRI
  • kidney graft biopsy
  • blood samples
  • urine specimens
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Where

1 site
Hôpital Edouard Herriot, Hospices Civils de Lyon
Lyon, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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