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โ† Trials
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Early Cessation of Sedation and TTM in Patients With a Favourable EEG After Cardiac Arrest

RecruitingNAAges 18 Years - anyAllMedisch Spectrum Twente
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In plain words

What the trial is, and whether it could suit you

The objective of this study is to estimate the feasibility and safety of early weaning from ICU treatment in patients after cardiac arrest and an early (\< 12 h) favourable EEG pattern (indicating no or mild postanoxic encephalopathy).

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Patients after cardiac arrest admitted to the ICU for treatment with sedation, TTM and mechanical ventilation. * Age 18 years or older. * Continuous EEG measurement started within 12 hours after cardiac arrest. * Favourable EEG pattern within 12 hours after arrest, defined as a continuous background pattern (NVN, 2019; Ruijter et al., 2019). * Possibility to stop sedative treatment within three hours after identification of a favourable EEG pattern. * Written informed consent (deferred). Exclusion Criteria: * A known history of another medical condition with limited life expectancy (\<6 months). * Any progressive brain illness, such as a brain tumour or neurodegenerative disease. * Pre-admission Glasgow Outcome Scale Extended score of 4 or lower. * Reason other than neurological condition to continue sedation and/or ventilation. * Follow-up impossible due to logistic reasons.
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What it tests

  • Early cessation of sedation and TTM
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Where

2 sites
Rijnstate hospital
Arnhem, Netherlands
Medisch Spectrum Twente
Enschede, Netherlands
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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