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CRACK-TARGET 1: Descriptive Study of Observed Behavioral Sensitization and Expectations

RecruitingNAAges 18 Years - anyAllAssistance Publique - Hôpitaux de Paris
NCT06050304 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This research focuses on behavioral sensitization (BS) a specific behavioural disturbance in crack-cocaine addiction. The primary objective is to observe whether BS can be demonstrated in an ecological setting in crack dependent users by continuous actimetry for 3 weeks. It is planned to include 20 persons with a current crack-cocaine addiction with a preferential use of rapid administration route (intravenous or smoke), in a care institution: Fernand Widal Hospital. In the proposed research, the investigators will assess the movements of crack-cocaine dependent users in relation to consumption. They will have to wear continuously for 3 weeks an actimeter. They will also have 3 blood tests trying to identify biomarkers of BS.

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📋 Eligibility rules (as published)
Inclusion Criteria: * \> 18 years * Have a current crack-cocaine use disorder defined as Severe Intensity Use Disorder (6 or more DSM5 criteria), AND preferential use of rapid administration route (intravenous or smoked) * Self-identified male or female (n=10 males, n=10 females) * Negative pregnancy test for females and use of effective contraception * Be affiliated with a social security plan (or PUMA or CSS or AME) * Sign an informed consent and commit to a 3-week follow-up in the study * Have a weight greater than 40 kg Exclusion Criteria: * • Patient with a psychiatric disorder or symptoms that are not currently stabilized * Patient who is a minor or under protective supervision (curatorship or guardianship) * Patient in care at the request of a judicial authority (therapeutic injunction, classification with orientation) * Pregnant or breastfeeding women * Patients who do not speak French or English sufficiently * Patients weighing less than 40 kg
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What it tests

  • Observation of behavior and search of biomarkers with 3 blood tests.3 weeks wearing an actimeter
  • 3 blood tests
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Where

2 sites
Centre 001_Hôpital Fernand Widal
Paris, France
Hôpital Fernand Widal
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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