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Decremental Esophageal Catheter Filling Volume Titration For Transpulmonary Pressure Measurement

RecruitingNAAges 1 Month - 18 YearsAllDr. Behcet Uz Children's Hospital
NCT06051292 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Mechanical ventilation is a critical intervention in the management of pediatric patients with respiratory distress. During this process, accurate measurement of transpulmonary pressure (PL) is essential to ensure the safety and efficacy of ventilation. PL is defined as the difference between alveolar pressure (Palv) and pleural pressure (Ppl). While the direct measurement of Ppl is possible, it poses a risk to tissue integrity. Thus, the primary surrogate for Ppl measurement today is esophageal pressure (Pes). However, the measurement of Pes is not without challenges. This abstract outlines the pitfalls associated with Pes measurement, emphasizing the importance of employing well-defined procedures to mitigate potential errors. These errors can range from underestimation of Pes due to underfilled catheters to overestimation resulting from overfilled catheters. To address these challen

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📋 Eligibility rules (as published)
Inclusion Criteria: * Pediatric patients between 1 months and 18 years * Patients need mechanical ventilation support without modification of ventilation settings within the upcoming 2 hours * Informed consent was signed by next of kin * Requiring esophageal catheter application Exclusion Criteria: * Patients eligible for extubation or modification of ventilation settings within the upcoming 2 hours * Patient included in another interventional study in the last 30 days * Patients unable to undergo esophageal catheter insertion due to congenital or acquired pathologies * Patient included in another interventional research study under consent * Patient already enrolled in the present study in a previous episode of acute respiratory failure
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What it tests

  • Fast method
  • Conventional method
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Where

4 sites
Aydin Obstetric and pediatrics Hospital
Aydin, Turkey (Türkiye)
Erzurum Regional Research and Training Hospital
Erzurum, Turkey (Türkiye)
Cam Sakura Research and Training Hospital
Istanbul, Turkey (Türkiye)
The Health Sciences University Izmir Behçet Uz Child Health and Diseases Research and Training Hospital
Izmir, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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