Validation of Biomarkers Performance to Reduce Antibiotics overUse in newBorns With Suspected Clinical Signs of InfectionS

Inclusion Criteria: * Patient hospitalized in the NICU of one of the two recruiting centers at the time of inclusion * Patients aged ≥ 7 days * Patients weighted ≥ 500 g the day of blood sample * patients with suggestive signs of LOS including at least one of the following:Fever \> 38°C; tachycardia \> 160bpm; capillary refill time \> 3 seconds; grey and/or pale skin complexion; apnea/ bradycardia syndrome, bloating; vomiting; rectal bleeding; hypotonia; lethargy; seizures without other obvious cause; increased ventilatory support and/or increased FiO2; cutaneous rash; inflammation at the needle-puncture site of the central venous catheter; or any other condition for which the clinician suspected an infection * patients with a standard of care blood sampling, including at least a blood culture; Exclusion Criteria: * Patient treated with antibiotics for a bacteriologically confirmed infection at the time of sampling or within 48 hours prior to sampling * Patient who underwent surgery within the previous 7 days * Patients vaccinated within the previous 7 days * Patient who received treatment with systemic corticosteroid therapy in the 48 hours prior to sampling * Patient with severe combined immunodeficiency * Opposition from parent(s)/guardian(s)