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Premorbid Personality Profile of Patients With Cognitive and Behavioral Disorders

Recruitingn/aAges 18 Years - anyAllNantes University Hospital
NCT06059313 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Damages in frontal area present in neurodegenerative disease (frontotemporal degeneration, frontal variant of Alzheimer disease) and in psychiatric disease (bipolar disorder) can affect behavior and cognition including social cognition. Symptoms vary both quantitatively and qualitatively from disease to another and from person to person. It cannot be completely excluded that in some cases, factors of susceptibility such as premorbid personality traits lead to frontal fragility. The study will assess the relationship between premorbid profile using NEO-PI 3 inventory and cognitive and behavioral/psychobehavioral manifestations in patients with behavioral variant of frontotemporal disorder (bvFTD), phenocopy frontotemporal dementia (phFTD), frontal variant of Alzheimer disease, bipolar disorder characterized with frontal damages.

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📋 Eligibility rules (as published)
Inclusion Criteria : * Patients with behavioral variant of frontotemporal disorder (bvFTD) according to Rascovsky criteria (2011) or patients with phénocopy frontotemporal dementia (phFTD) who fulfill criteria for possible bvFTD and have no imaging abnormalities or patients with frontal variant of Alzheimer disease according to Ossenkopele criteria (2022), or patient with bipolar disorder according to CIM 10 criteria * Score for Mini-mental state examination ≥ 18 * Patient with caregiver who has who has known him/her in the 10 years preceding the disease onset. * Patient and caregiver consents (no opposition) Exclusion Criteria : * Patient with no caregiver * Pregnant or breast feeding women
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What it tests

  • Submission of the NEO-PI-3 questionnaire
  • Submission of the Interpersonal Reactivity Index questionnaire (IRI)
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Where

1 site
CHU de Nantes
Nantes, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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