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Cryopreservation of Prepubertal Testicular Tissue for Preservation of Fertility in Young Boys With Cancer

RecruitingNAAges 1 Day - 18 YearsMaleUniversity of Edinburgh
NCT06063551 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Prepubertal boys treated for cancer are at risk of infertility as a result of their treatment. At present there are no options to preserve fertility in these boys. With informed consent, the investigators aim to cryopreserve (freeze) testis tissue biopsies taken from boys undergoing cancer therapy with a high risk of infertility. A portion of cryopreserved tissue will be securely stored, which in the future may be used to restore fertility in the patients. A second portion of the tissue will be used for laboratory work aimed at understanding the conditions required for development of the germ cells. Patients will be recruited from the Oncology Department at the Royal Hospital for Children and Young People (RHCYP) in Edinburgh. Tissue will be obtained from prepubertal patients with cancer who are about to undergo treatment with a high risk (\>80%) of infertility. Informed consent will be

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📋 Eligibility rules (as published)
Inclusion Criteria: * Pre- and peripubertal boys * Due to receive cancer treatment that is predicted to have a high risk (\>80%) of infertility * Consent to removal of testicular tissue for storage and research * Unable to produce a semen sample by masturbation Exclusion Criteria: * Participation in study would delay treatment * Too unwell to undergo the procedure * Pre-existing testicular pathology/previous testicular surgery (eg orchidopexy) * Able to produce a semen sample for cryopreservation
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What it tests

  • Testicular Biopsy
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Where

1 site
University of Edinburgh
Edinburgh, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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