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Potential Diagnostic Biomarkers for Aortic Dissection in the Emergency Department

Recruitingn/aAges 18 Years - anyAllChinese University of Hong Kong
NCT06065306 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this observational study is to determine the utility of desmosine, D-dimer and aggrecan as early diagnostic biomarkers in aortic dissection. The main questions it aims to answer are: * To investigate the plasma levels of selected biomarkers in ED patients with confirmed aortic dissection * To study the diagnostic performance of plasma levels of selected biomarkers for aortic dissection * To study the association between plasma levels of selected biomarkers and clinical outcomes

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years * Presentation to the ED with first 24 hours of symptoms suggesting AD, including chest pain, upper back pain, syncope of unknown cause, symptoms of any acute perfusion deficit * Confirmed AD * the diagnosis of AD adjudicated by an independent expert panel at hospital discharge or death, whichever comes first * The expert panel will consist of (1) a specialist in Emergency Medicine and (2) a specialist in Cardiology and (3) a specialist in Cardiothoracic Surgery. Exclusion Criteria: * Age \<18 years old * Pregnancy * Surgery or stenting performed before recruitment
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What it tests

  • Not listed
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Where

1 site
Prince of Wales Hospital
Shatin, Hong Kong
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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