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Neural Plasticity and Motor Recovery After Upper Extremity Motor Training in People With c-SCI

RecruitingNAAges 16 Years - 90 YearsAllAnnemie Spooren
NCT06065384 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

After spinal cord injury (SCI), there is a disruption in neural circuits resulting in paralysis. There is not yet a cure for paralysis. In persons with Cervical SCI (pwC-SCI) recovery of arm-hand function is very important as it has a significant impact on the patients' level of independence and quality of life. Recovery is assumed to involve alterations in both central and peripheral motor systems. Motor training at an intensive dosage potentially provides a powerful stimulus for neurological recovery. This project exploits the peripheral and central neuroplastic effect of an early (\<13 weeks after injury) and intensive (8 weeks of 6 hours in addition to usual care) upper limb motor training program (EIUMT) directed at recovery below the level of the injury in pwC-SCI within an international multi-center randomized controlled trial including 44 pwC-SCI. It has 4 objectives: to investig

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📋 Eligibility rules (as published)
Inclusion Criteria: * Traumatic or non-traumatic C-SCI in the preceding 13 weeks; age over 16 years; have an incomplete SCI categorized as AIS C or D or an AIS A SCI with zones of partial motor paralysis (as defined by the International Standards for the Neurological Classification of SCI (ISNCI) and medically stable. Exclusion Criteria: * SCI with ASIA Impairment Scale (AIS) A without zones of partial preservation (decided based on former studies) and expertise of the team; SCI with any significant medical condition that could prevent the person from participating. Patients will be excluded from the measures of central plasticity in the presence of contraindications for TMS application such as epilepsy, metal implants in the brain, defibrillator, pacemaker, and pregnancy
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What it tests

  • experimental group: intensive motor training
  • usual care
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Where

4 sites
Revalidatieziekenhuis RevArte
Antwerp, Belgium
UZGent
Ghent, Belgium
UZLeuven Campus Pellenberg
Leuven, Belgium
Zorggroep Adelante
Hoensbroek, Netherlands
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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