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โ† Trials
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The ALOFT Pilot Trial

RecruitingNAAges 18 Years - anyAllOttawa Hospital Research Institute
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In plain words

What the trial is, and whether it could suit you

The ALOFT Pilot Trial will evaluate three pragmatic elements (recruitment, adherence, and follow-up) of neuraxial versus general anesthesia for lower limb revascularization surgery that are necessary to support a successful, large-scale evaluation. We will concurrently use implementation science methodology to further refine processes for the larger trial. The future full ALOFT trial will be designed to evaluate the comparative effectiveness of two different anesthesia types for improving outcomes.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Age โ‰ฅ18 years 2. Planned lower limb revascularization surgical procedure (on an elective or urgent basis): infrainguinal arterial bypass, femoral endarterectomy, patch angioplasty 3. Able to access a telephone for postoperative follow-up Exclusion Criteria: 1. Absolute contraindications to neuraxial anesthesia: impaired coagulation state (due to intrinsic, congenital or extrinsic (i.e., anticoagulant not held for guideline recommended period based on the American Society of Regional Anesthesia recommendations) factors), infection at the needle insertion point, increased intracranial pressure or intracranial mass, uncorrected hypovolemia or hypotension (systolic blood pressure \<90 mmHg), severe uncorrected aortic stenosis) 2. Traumatic arterial injuries as an indication for surgery 3. Multiple sclerosis or demyelinating central nervous system conditions 4. Known malignant hyperthermia or who require a malignant hyperthermia trigger-free anesthetic 5. Pregnancy 6. Prior enrollment in this study, or participating in another interventional trial that could interfere with interpretation of data for either study (may be acceptable if unrelated interventions/outcomes and study PIs mutually agree in writing to co-enrollment) 7. Determination by the surgeon, anesthesiologist, or other clinician, that the patient would not be suitable for randomization
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What it tests

  • neuraxial anesthesia
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Where

1 site
The Ottawa Hospital
Ottawa, Canada
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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