Effect of MOPs During Orthodontic Movement in Periodontitis Patients

Inclusion Criteria: Patients will be included if agreeing to undertake combined periodontal and orthodontic therapy following the clinical practice guideline of stage IV periodontitis patients, and fulfilling the following criteria: * adult patients older than 18-year-old; * systemically healthy (see exclusion criteria); * diagnosed as stage IV (Papapanou et al., 2018) case-type 2 (Herrera et al. 2022) periodontitis; * the presence of at least one flared tooth of the upper-anterior sextant with an intrabony defect (intrabonny component \<5mm) (experimental teeth); * in need of orthodontic therapy. Exclusion Criteria: * systemic diseases (diabetes mellitus, obesity, cardiovascular diseases); * any medication that could affect the level of inflammation, (such as chronic antibiotics, phenytoin, cyclosporin, anti-inflammatory drugs, systemic corticosteroids, or calcium channel blockers); * pregnant or lactating woman; * inability to respond questions or to attend follow-up visits; * extreme skeletal malocclusions requiring orthognathic surgery; * patients smoking more than 10 cigarettes/day; and * the presence of PD greater or equal to 5mm with BOP after step 3 of periodontal therapy