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Non-invasive Diagnosis of Coronary Microvascular Disease: Pilot Study

Recruitingn/aAges 18 Years - anyAllUniversity of Leicester
NCT06070662 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

* 40% of patients presenting with stable chest pain (angina) have no significant blockage of the main heart arteries. Identifying why these patients have symptoms will mean better treatment options can be developed. * About 60% of these patients have evidence of coronary microvascular disease (CMD). In this condition there is a problem with the heart's microvessels (very small blood vessels that branch from the main heart arteries). Due to problems with these vessels there is a mismatch between the blood supply to the heart and its oxygen consumption, causing chest pain and this can also lead to major heart events. * At present, to diagnose this condition, specialised techniques during an invasive test, called a coronary angiogram, are required. As this is an invasive test, it can be lead to complications and cause discomfort. * Non-invasive ways of diagnosing CMD are required to improve

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📋 Eligibility rules (as published)
Inclusion Criteria: * Current participant of the 'CMR versus CT-FFR in CAD' study * Continue to meet the inclusion criteria for the main study: * Patients aged ≥18 years * Referred for invasive coronary angiography for investigation of chest pain * Willing and able to give informed consent * Willing and able (in the Investigators opinion) to comply with all study requirements. * Willing to allow his or her General Practitioner and consultant, if appropriate, to be notified of participation in the study. * Able to understand written English * Able to perform exercise in the MRI scanner Study arm: * No evidence of obstructive or non-obstructive CAD on research CTCA * Myocardial perfusion defect detected on adenosine stress CMR indicative of CMD Control arm: • Evidence of multivessel CAD on research CTCA Exclusion Criteria: * Meet the exclusion criteria for the main study: * Recent acute coronary syndrome (\< 6 months) * Severe claustrophobia * Absolute contraindications to CMR - those with MR conditional or safe devices will be included * Second-/third-degree atrioventricular block * Severe chronic obstructive pulmonary disease * Moderate-severe asthma * Estimated glomerular filtration rate \<30 ml/min/1.73m2 * Women who are pregnant, breast-feeding or of child-bearing potential (premenopausal women) * Contraindication to iodinated contrast * Participants who have participated in a research study involving an investigational product in the past 12 weeks * Patients unable to understand written English
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What it tests

  • Coronary microvascular disease testing during coronary angiography
  • Cardiac magnetic resonance scan including exercise
  • Additional analysis of already acquired CT scan
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Where

1 site
Glenfield Hospital, University Hospitals of Leicester
Leicester, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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